The present study shows that, after controlling for age, sex, BMI, smoking, drinking, anti-HBc, and family history of hepatitis B, an accelerated HBV immunization schedule was associated with significantly lower anti-HBs seroconversion rate than the standard immunization schedule (OR: 0.560, 95% CI: 0.318–0.988). The gene discussed is KRT88P; the disease is hepatitis B virus infection.