Covariance analysis showed that, after controlling for age, gender, BMI, smoking, drinking, anti-HBc, and family history of hepatitis B, the calibrated anti-HBs GMC was 72.473 mIU/ml (95% CI: 57.429–91.325) in the accelerated group and 141.219 mIU/ml (95% CI: 116.850–170.187) in the standard group; the calibrated value was significantly lower in the accelerated group (F = 19.287, P<0.001; Table 4). Here, KRT88P is linked to hepatitis B virus infection.