Strikingly, a very recent report combined two-stage functional annotation study based on two data bases (TCGA (http://cancergenome.nih.gov) and GEO (http://www.ncbi.nlm.nih.gov/geo/), as well as in vitro transfection experiments on lung cancer cells has provided strong evidence that RAGE may act as a tumour suppressor gene to regulate lung cancer development[25]. The gene discussed is AGER; the disease is lung cancer.