Although RAGE is highly expressed in normal alveolar epithelium, it is surprisingly and markedly reduced in lung carcinomas, RAGE over-expression in normal lung alveolar type I epithelial cells is followed by rapid down-regulation upon malignant transformation, being associated with increased aggressiveness in non-small cell carcinomas and adenocarcinomas[11-13]. Here, AGER is linked to non-small cell lung carcinoma.