ADHD, anxiety disorder and depressive disorder were not significantly different between the two genotypes, but it was interesting to observe that all three showed higher absolute frequencies in association with TSC1 rather than TSC2 (ADHD TSC1 = 17.6%; TSC2 = 16%, P = 0.6881; Anxiety disorder TSC1 = 10.1%; TSC2 = 8.6%; P = 0.7809; Depressive disorders TSC1 = 10%; TSC2 = 5.2%; P = 0.0509) (Table 4). This evidence concerns the gene TSC1 and depressive disorder.