The specific mechanism underlying FBP1 downregulation is associated with promoter methylation and copy-number loss, leading to decreased FBP1 mRNA expression [22, 35] or post-transcriptional modification of FBP1 protein mediated by MAGE-TRIM28 complex, which results in FBP1 degradation in cancer cells [27]. The gene discussed is FBP1; the disease is cancer.