However, the development of immunity to malaria depends on the balance between cytophilic (IgG1 and IgG3) and non-cytophilic IgG antibodies (IgG4), which interfere with the binding of Fcγ receptors with cytophilic antibodies, complicating the immune response [5, 19, 20]. The gene discussed is IGHG3; the disease is malaria.