In SCLC cells, curcumin suppressed cell proliferation, migration, invasion, and angiogenesis through inhibiting the signal transducer and activator of transcription 3 (STAT3) and downregulating the expression of STAT3-regulated gene products (Cyclin B1, Bcl-XL, survivin, vascular endothelial growth factor, MMP-2, -7, and intercellular adhesion molecule-1) [140]. The gene discussed is STAT3; the disease is small cell lung carcinoma.