We found that miR-29b-3p and miR-29a-3p regulate SGK1; miR-335-5p, miR-125b-5p and miR-193b-3p regulate SHMT1; miR-130a-3p regulates GJA1; and miR-18a-5p and let-7i-5p regulate THBS1. This analysis indicates that the deregulation of these molecules can be associated with more aggressive tumor phenotypes. The gene discussed is SHMT1; the disease is neoplasm.