NR0B1 and chronic primary adrenal insufficiency: The cyp11a transcriptional activity was reported to be regulated by trans-regulators such as members of the orphan nuclear receptor superfamily NR5a2 (previously called SF-1, steroidogenic factor 1) and NR0b1 (previously called DAX-1, dosage-sensitive sex reversal, adrenal hypoplasia congenital critical region, on chromosome X, gene 1) [11,12,13].