Previous studies have shown that mangiferin can inhibit mastitis induced by LPS via suppressing NF-κB and NLRP3 signaling pathways, and resveratrol inhibits LPS-induced mice mastitis through attenuating the Mitogen-activated protein kinase (MAPK) and NF-κB signaling pathway [6,7]. The gene discussed is NFKB1; the disease is mastitis.