Other modifiable exposures, such as cardiometabolic risk factors (e.g., body mass index, waist-to-hip ratio, blood pressure, fasting insulin, fasting glucose, and cholesterol levels), were not associated with AD in a recent Mendelian randomization study based on the IGAP dataset [12] and, therefore, are unlikely confounders of the association of S-25OH with AD. Here, INS is linked to Alzheimer disease.