CYP17A1 and posterior cortical atrophy: Following this, in 2017 the combination of ADT and the high-affinity irreversible cytochrome P450 17A1 (CYP17A1) inhibitor abiraterone with a glucocorticoid has been established as a new standard of care for patients with metastatic PCa based on the results of the STAMPEDE and LATITUDE trials [126,127].