Based on an integrative clustering approach using somatic mutations, gene fusions, SCNA, gene expression, and DNA methylation in 333 primary PCa samples, The Cancer Genome Atlas (TCGA) project defined seven major subtypes [18]: Tumors harboring fusions involving E-twenty-six (ETS) genes comprised the majority of the cohort (59%), with (i) 46% ERG rearrangements, followed by (ii) ETV1 (8%), (iii) ETV4 (4%), and (iv) FLI1 (1%). The gene discussed is ERG; the disease is posterior cortical atrophy.