Among molecular chaperones, Heat Shock Proteins (HSPs) are major constituent of the chaperome and Hsp60 [13], Hsp70 [14,15,16] and Hsp90 [17,18] are considered target [19] of particular relevance in AD [20] and for many other diseases, including cancer [21,22,23,24]. The gene discussed is HSPD1; the disease is Alzheimer disease.