PDCD1 and neoplasm: The immune-suppressive environment in the ovarian tumor, rich in TGF-β, IL-10, VEGF, ARG-1, along with inhibitory molecules such as IDO, PD-1, and PD-L1, drives the differentiation of CD14+CD1a- immature myeloid cells, anergic T cells and Tregs, induces tolerance, and promotes tumor growth [49,108,109].