EVs carry molecules such as CD24, and epithelial cell adhesion molecule (EPCAM1), which directly regulate cancer-cell migration, proteases (MMP2, MMP9), which promote ECM degradation and cancer invasiveness [160,163,164], or EV-associated mRNAs, such as miR21, which may induce resistance to paclitaxel [163,165,166]. This evidence concerns the gene MMP2 and cancer.