Several other molecules in the tumor endothelium, such as programmed cell death-1 ligand (PD-L1), B7-H3, arginase-1 (ARG-1), indoleamine 2,3, dioxygenase (IDO), IL-10, and PGE2, released by endothelial cells, downregulate TIL function or kill CD8+ effector TILs [45,46,47,48,49]. The gene discussed is CD274; the disease is neoplasm.