As we recently published, quantitative Tandem Mass Tag (TMT) isobaric labeling quantitative proteomics analysis revealed that gp120 causes upregulation of a number of proteins involved in glycolysis and in the tricarboxylic acid (TCA) cycle in glioma cells including enolase 2 (ENO2), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and malate dehydrogenase [32]. This evidence concerns the gene ENO2 and central nervous system cancer.