Additionally, the study revealed a strong increase in glycolysis (extracellular acidification) of 50 to 200% in response to 7–10 days gp120 treatment in the three glioma cell lines tested, with the highest increase observed in U87 cells (200%) and the smallest response in 965 cells (50%) (Figure 7A). This evidence concerns the gene ITIH4 and central nervous system cancer.