Moreover, the chemical induction of Hmox1 (the gene which codes for HO-1) reduces the pathogen load of macrophages infected with Trypanosoma cruzi [84], and in vivo experiments with Hmox1-KO, or myeloid-specific Hmox1-deficient animals showed that these are more susceptible to sepsis caused by E. coli or Listeria monocytogenes [85]. The gene discussed is HMOX1; the disease is Sepsis.