Nevertheless, blockade of FGF receptors has been shown to improve LVH, myocardial fibrosis and cardiac function and to reduce cardiac mRNA expression of pro-hypertrophic markers (α-MHC, β-MHC, ANP and B-type natriuretic peptide (BNP)) in 5/6 nephrectomy rats with FGF23 excess [95]. This evidence concerns the gene FGF23 and Myocardial fibrosis.