In an experimental study using a progressive CKD rat model treated with anti-FGF23, effects of FGF23 on phosphate excretion and reduced 1,25-dihydroxyvitamin D production were attenuated by neutralizing FGF23 levels thereby confirming a causative role of FGF23 in phosphate and vitamin D regulation [62]. Here, FGF23 is linked to chronic kidney disease.