An assessment of chromosomal imbalance using array comparative genome hybridization and WGA-DNA from two to five separate tumor areas of 14 GBMs demonstrated that there was a list of genetic alterations that were common to all tumor areas, including amplifications in 1q32.1 and 12q15, which contain MDM4 and MDM2 [42]. The gene discussed is MDM4; the disease is neoplasm.