One of the most efficient molecules for p53 restoration, PRIMA-1 (2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one), was discovered from a functional screening of the NCI drug library in cancer cells based on its ability to re-activate wt-p53 properties from select p53 missense mutants [124] (Figure 4). The gene discussed is TP53; the disease is cancer.