Crude organic extracts of turmeric-inhibited lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF)-α (IC50 = 15.2 μg/mL) and prostaglandin E2 (PGE2; IC50 = 0.92μg/mL) in human leukemia (HL-60) cells [181]. This evidence concerns the gene TNF and leukemia.