Regarding to anti-inflammatory cytokines, there was a decrease on IL-10 (1131 ± 42.52 pg/mL) and IL-4 (400.6 ± 18.19 pg/mL) levels in HE-02-treated animals, when compared to their control groups (1410 ± 37.25 pg/mL and 456.9 ± 16.67 pg/mL, respectively). This evidence concerns the gene IL4 and hereditary elliptocytosis.