Considering the increase in the concentrations of IL-1β and TNF-α observed after treatment with HE-02, it is possible to infer that this compound modulates the inflammatory response, which may explain the antitumor effect of HE-02 from the activation of macrophages and neutrophils that would be producing ROS and NO to induce cytotoxicity against tumor cells. The gene discussed is TNF; the disease is neoplasm.