In normal network, PVT1 revealed a net binding preference towards the miR-200 family (Figure 3D), which antagonized to regulate the expression of hundreds of mRNAs that are known to be related to the cancer development and progression (e.g., GATA3, CDH1, TP53, TP63, TP73, RUNX1, and RUNX3). This evidence concerns the gene PVT1 and cancer.