PVT1 and cancer: At the heart of this phenomenon, there was the recently and widely studied oncogene PVT1 [44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63] that switched from being the first of the hubs in the normal MMI network to fall outside the list of nodes of the cancer network.