While the importance of p65 to global NF-κB cellular activity and the ease of examining activated phospho-p65 have made it the primary method for analyzing NF-κB in GBM tissue [13,37], other subunits, such as p52 or relB, that are not as easily examined in vivo as phospho-p65, also play an important role in overall GBM pathobiology [10,38,39]. Here, RELA is linked to glioblastoma.