In mouse embryonic fibroblasts, TNFα induces twist1 by a mechanism that requires p65 [50] and in human mesenchymal lung cancer cells, expression of the IκBα super-repressor (IκBα-SR), which specifically inhibits canonical NF-κB signaling, blocks TNFα-induced TWIST1 expression [51]. The gene discussed is NFKBIA; the disease is lung carcinoma.