EZH2 and neoplasm: Remarkably, the silencing of the EZH2 gene in vitro and in vivo (via systemic siRNA nanoparticle delivery in both EOC cells and TECs in mouse EOC xenografts) substantially increased vasohibin-1 expression and reduced neoangiogenesis and tumor growth [197], underlining the additional therapeutic potential of concomitant EZH2 targeting in TECs and EOCs.