KDM3A and melanoma: Using a panel of distinct cancer type cells, including cervical, hepatocellular, epidermoid carcinomas, glioblastoma, rabdomyosarcoma, and murine melanoma, Osawa and co-authors [231] demonstrated that cancer cell hypoxia and nutrient starvation lead to activation of histone demethylase JMJD1A (Jumonji domain-containing 1A), followed by increased AKT phosphorylation, cancer cell metastatic properties, increased angiogenesis, and infiltration of macrophages into cervical cancer and muscle sarcoma tissues in vivo.