EZH2, a histone-lysine N-methyltransferase, is frequently overexpressed in ovarian tumor tissues and is a well-established epigenetic mediator (stimulator) of EOC tumor growth, invasion, metastasis, neoangiogenesis, platinum-resistance and ovarian cancer stem cell renewal through transcriptional repression of signaling pathways, as well as direct/indirect interaction with multiple miRNAs and lncRNAs (reviewed in [196]). The gene discussed is EZH2; the disease is ovarian cancer.