EZH2 and cancer: The histone mark H3K27me3 in breast CAFs was shown to be reduced, along with decreased expression of enhancer of zeste homolog 2 (EZH2), a methyltransferase that is responsible for the H3K27me3 histone mark [120], resulting in promotion of cancer cell invasion by CAFs via upregulated thrombospondin type 1 motif 1 [121].