Gül et al. showed in mice inoculated with B16F10 melanoma cells that unstimulated Kupffer cells could bind, but not eliminate tumor cells circulating into the liver; interestingly, when stimulated with a tumor-specific, anti-gp75 mAb, Kupffer cells efficiently removed tumor cells in an ADCP-mediated manner. This evidence concerns the gene TYRP1 and neoplasm.