Given that MBG signals through the NKA and NKA signaling is known to stimulate the mTOR system, which has been implicated in the development and progression of renal disease, we speculated that Rapamycin, an inhibitor of mTOR, may significantly attenuate the cardiomyopathy induced by partial nephrectomy or MBG infusion. The gene discussed is MTOR; the disease is kidney disorder.