Direct evidence for a tumour suppressive role includes ELF5 silencing in epithelial-like T47D breast cancer cells inducing EMT, and ELF5 re-expression in mesenchymal-like MDA-MB-231 cells inducing epithelial features and reducing metastasis in vivo, at least in part by repressing expression of SNAIL2 [51]. The gene discussed is ELF5; the disease is breast carcinoma.