ELF5 and central nervous system cancer: Amplification of ELF5 occur in cancers of the upper GI tract (oesophageal and stomach), ovary, head and neck, and breast in 2–6% of cases, while occasional deletions of ELF5 occur in prostate, sarcoma, bladder, and lung cancers as well as acute myeloid leukemia (AML) and gliomas (Figure 5).