Although TG2−/− mice have shown that there is no role for TG2 in glucose homeostasis, at least in mice [94], in diabetic mice, hyperglycemia influences the activation of TG2 via vascular endothelial growth factor (VEGF) in endothelial cells as well as dissociation of beta-catenin from vascular E-cadherin and subsequent adherens junction dissolution, along with the stress fiber formation [95], thus showing the role of TG2 in endothelial–mesenchymal transition (EndoMT) in diabetic mice. This evidence concerns the gene TGM2 and Hyperglycemia.