Recently, it was shown that 2D migration of epidermal cancer stem cells (ECS) is significantly reduced by transamidase site-specific inhibitors (NC9, VA4, VA5 and CP4d), that by interacting with the transamidase catalytic center produce a conformational change thus inactivate TG2 GTP binding site, necessary for cancer stem cell survival and migration [109,110] Additionally, in D54 glioma cells, the formation of blebs is dependent on Ca2+. The gene discussed is TGM2; the disease is central nervous system cancer.