Reimers and colleagues tried to generate a cocktail of prognostic factors for CRC (including MSI, TP53, KRAS (codons 12, 13), BRAF, EGFR, M30, Ki67, 18q LOH, CIMP, CIN, PIK3CA, TS, DPD etc.)which allowed an approach but no secure selection for individualizing multimodal therapy in CC or RC [39]. This evidence concerns the gene PIK3CA and colorectal carcinoma.