FAP has an APC gene mutation (APC type; 60% of all CRCs), while in HNPCC the germ chromosomes are mutated in their DNA information for MMR genes (MLH1, MSH2, MSH6, PMS1, and PMS2) leading to MSI (MSI type) [40,41,69]. This evidence concerns the gene MLH1 and hereditary nonpolyposis colon cancer.