Reimers and colleagues tried to generate a cocktail of prognostic factors for CRC (including MSI, TP53, KRAS (codons 12, 13), BRAF, EGFR, M30, Ki67, 18q LOH, CIMP, CIN, PIK3CA, TS, DPD etc.)which allowed an approach but no secure selection for individualizing multimodal therapy in CC or RC [39]. Here, TYMS is linked to colorectal carcinoma.