Available data are conflicting and inconclusive because they are based on retrospective analyses of small heterogeneous Saudi and non-Saudi patients.17-22Given these considerations, the main objectives of this study were to determine the prevalence and founder effect of BRCA1 and BRCA2 mutations in Saudi patients with BC and to study the clinicopathologic features of BC associated with these genetic mutations. This evidence concerns the gene BRCA2 and breast cancer.