Our study also analyzed differences in median OS between patients who would be eligible for clinical trials and patients who would not be eligible for clinical trials (KPS < 70, CNS metastasis, Hb < 9 g/dL, or any cardiovascular serious event, such as myocardial infarction unstable angina, or pulmonary embolism, in the last 12 months). Here, GSTM1 is linked to myocardial infarction.