CD4 and cerebral cavernous malformation: In the light of the high mortality associated with CCM, the challenges associated with early identification of subclinical CCM, the cost effectiveness of the screen-and-treat intervention (estimated to be cost-effective at a CrAg threshold of 0.6%),18,20,30 the high pickup rate of CCM in asymptomatic CrAg +ve patients,24,27 as well as the resources available in SA, serious consideration should be given to recommending LPs for all patients with a low CD4 count who are CrAg +ve.