Loss-of-function of polycystin-1 (PC1) or polycystin-2 (PC2), two trans-membrane proteins that form a heteromeric molecular complex in the cilia and plasma membrane, results in the most common life-threatening genetic renal disorder, called Autosomal Dominant Polycystic Kidney Disease (ADPKD), characterized by the formation and development of kidney cysts (Torres et al., 2007). Here, PKD2 is linked to Kidney Cyst.