GOT2 and familial pancreatic carcinoma: In pancreatic cancer, which is characterized by activating mutations in K-Ras in more than 90% of cases, mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) utilizes glutamine-derived glutamate and oxaloacetate (OAA) to generate aspartate that is then exported to cytosol.