In turn, acetyl-CoA starts lipid synthesis and sustains acetylation reactions (see section Post Translational Regulation In Cancer Metabolism) and influences a variety of biochemical circuitries involved in the neoplastic process, including histone acetylation and chromatin remodeling as well as redox homeostasis via acetylation of superoxide dismutase and IDH (1). This evidence concerns the gene IDH1 and cancer.