Transduction pathways deregulated in cancer, such as PI3K/Akt or Ras signaling, can limit Ca2+ flux to mitochondria inhibiting IP3Rs, whereas tumor suppressors such as PTEN, BRCA1 or PML favor Ca2+ release from IP3Rs and the subsequent increase in mitochondrial Ca2+ levels (159, 160). This evidence concerns the gene AKT1 and cancer.