Researchers have speculated that the protein deposits found in these neurodegenerative diseases may develop and spread throughout the brain in a manner analogous to that of aggregation of the prion protein (PrP) in transmissible spongiform encephalopathies (TSEs), such as Creutzfeldt-Jakob disease (CJD) [1,3]. The gene discussed is PRNP; the disease is neurodegenerative disease.