In agreement with previous findings in glioma cells [20, 31], we found that SPIN1 overexpression upregulated CYCD1. SPIN3, which has not yet been described, and which we found to be pro-apoptotic, downregulated CYCD1. Consequently, SPIN1 appears to play a pro-oncogenic role in TCam-2 cells, while SPIN3 is a tumor suppressor. This evidence concerns the gene SPIN3 and central nervous system cancer.