CtBP upregulation leads to inappropriate cell survival as well as enhanced migratory and invasive properties due to the ability of CtBP to repress transcription of Bik [9], Brca1 [4], PTEN [10], the epithelial adhesion protein E-cadherin [11], and many other tumor suppressive genes [11, 12], as well as co-activate the migration-associated gene Tiam1 [13] and the drug efflux pump MDR1 [14]. The gene discussed is CTBP1; the disease is neoplasm.