Interestingly, the few adenomatous polyps from Ctbp2+/-Apcmin/+ mice exhibited significantly diminished CD133+ expression (Figure 1D-1E), along with markedly less proliferative potential, as determined by Ki-67 staining, towards the edge of the polyp (Supplementary Figure 1C), as compared with Apcmin/+ adenomas. This evidence concerns the gene PROM1 and adenoma.