CTBP2 and neoplasm: In this work we have interrogated the effect of Ctbp2 haploinsufficiency on the intestinal stem cell niche of both wild type and Apcmin mice, to better understand Ctbp2’s biologic role in the expanded stem cell population in Apcmin mice that serve as precursors to polyps, which are enriched for cells with stem cell-like markers that are characterized as tumor initiating cells (TIC’s).