Although our study included a more wide disease clinical spectrum, this finding of decreased miRNA155 with increased disease activity was shown before in ocular BD through Zhou et al., 2012 [24] which stated that miRNA155 expression levels in PBMCs and DCs was decreased in BD patients suffering from active uveitis and overexpression of miRNA155 in DCs increased the inhibitory interleukin 10 (Il 10) and decreased Il6 and Interleukin 1B (Il1B) expression which are pro-inflammatory cytokines which may contribute to disease flare. This evidence concerns the gene IL1B and Behcet disease.