Increased parasitaemia and mortality Increased expression of IL-4, IL-13, and IL-22 in spleen cells at early infection, later normalized Increased frequency of CD4+IFN-γ+and CD4+IL-17+ cells in spleen Increased IL-17A secretion by spleen cells upon ex vivo restimulation with anti-CD3 antibody at 7 dpi, normalized at 14 dpi Increased secretion of IL-4 upon ex vivo restimulation with anti-CD3 antibody. Improved survival rate upon in vivo anti-IL-4 treatment. This evidence concerns the gene CD4 and infection.