HS3ST5 and metastatic neoplasm: Interestingly, alterations were found in only non-metastatic tumors, affecting N-sulfation, and the isoforms of heparan sulfate 6-O-sulfotransferase 1 (HS6ST1), heparan sulfate-glucosamine 3-sulfotransferase 3B1 (HS3ST3B1) and heparan sulfate-glucosamine 3-sulfotransferase 5 (HS3ST5) (128).