MAPT and Alzheimer disease: For example, combined expression of mutant APP, Tau and Presenilin1 in 3xTg-AD mice produces progressive RGC degeneration, Aβ deposition and Tau phosphorylation in a similar fashion to what can be observed in the brain (Perez et al., 2009; Edwards et al., 2014; Chiasseu et al., 2017).