Patients who had received sunitinib versus pazopanib as the only prior VEGFR TKI had a higher incidence (≥5% difference) of the following grade 3/4 AEs: diarrhoea (15% versus 9%), nausea (7% versus 1%), and anaemia (8% versus 3%) for cabozantinib-treated patients, and anaemia (18% versus 9%) for everolimus-treated patients. This evidence concerns the gene KDR and anemia (phenotype).