YTHDF2 and Infertility: Loss of the cytoplasmic reader YTHDF2 in fish impairs embryonic development as a result of defective maternal RNA clearance during maternal-zygotic transition (Zhao et al., 2017), while in mice loss of YTHDF2 results in defective maternal RNA metabolism during oocyte maturation, leading to female-specific infertility (Ivanova et al., 2017).