Kinesin-1-driven motility of JIP3/4 is involved in numerous cellular processes and diseases including axonal outgrowth, transport and damage signaling; muscle development, endosomal trafficking, Huntington's disease, and cancer (Bowman et al., 2000, Byrd et al., 2001, Cavalli et al., 2005, Edwards et al., 2013, Marchesin et al., 2015, Montagnac et al., 2009, Morfini et al., 2009, Schulman et al., 2014, Watt et al., 2015). Here, KIF5C is linked to cancer.