IGKV1D-37 and neuropathy: Although O4 is also capable of activating complement, its inability to bind this peripheral site gives the GAME antibodies an advantage in studying murine models of human disease, as demyelination of the nerve is observed with certain anti-sulfatide antibody-associated neuropathies and demyelination has been associated with complement activity (Rosenbluth and Moon, 2003; Storch and Lassmann, 1997).