Notch signaling pathway genes, DLL3 (MIM# 602768), MESP2 (MIM# 605195), LFNG (MIM# 602576), HES7 (MIM# 608059), RIPPLY2 (MIM# 609891), and TBX6 (MIM# 602427), are associated with somitogenesis and their mutations have been identified in SCD (Bulman et al., 2000; Giampietro et al., 2006; McInerney‐Leo et al., 2015; Sparrow et al., 2006, 2008, 2013 ; Whittock et al., 2004). This evidence concerns the gene LFNG and Schnyder corneal dystrophy.