We found significantly lower percentage of CD19+/CD5+TLR2+ cells in patients with CLL comparing to the control group that is in line with the data obtained by Grandjenette et al. (2007) and Muzio et al. (2008) who demonstrated lower expression of TLRs on leukemia cells as compared to normal B cells. Here, TLR2 is linked to B-cell chronic lymphocytic leukemia.