KEAP1 and acute liver failure: For instance, miR-125b attenuates paracetamol- and FAS-induced toxicity in hepatocytes and prevents acute liver failure (ALF) by directly targeting kelch-like ECH-associated protein 1 (Keap1);8 upregulation of miR-125b protects female mice from non-alcoholic fatty liver disease through repressing lipid accumulation in hepatocytes,9 and downregulation of miR-125b in cholangiocyte enhances proliferation of cholangiocytes during bile duct ligation (BDL)-induced cholestatic liver injury.10