Furthermore, compared with the livers from the control group, those from the miR-125b-sponge group displayed a lower level of miR-125b (Figure S5) and much less HSC activation and collagen deposition, as evidenced by reduced α-SMA and Sirius red staining (Figure 1G), and decreased hydroxyproline content in the livers (Figure 1H), suggesting an alleviation of hepatic fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.