GSK3B and breast carcinoma: It was reported that GSK3β inhibition causes a significant dysregulation of actin cytoskeleton organization and insufficiency of focal adhesion,23 further resulting in the suppression of cell invasion in colorectal cancer cells24 and renal carcinoma cells,25 whereas other studies showed that GSK3β mediates the invasion of non-invasive human lung cancer,26 breast cancer,27 and pancreatic cancer.28