As a new derivative of stilbene compound discovered to affect the competence of cancers, ISO at relevant applicable concentrations also effectively abolishes transcription factor specific protein 1 (Sp1) expression and transactivation, leading to the downregulation of bindings of Sp1 to the promoter region of its regulated genes, cyclin D1 and XIAP, and further suppression of cancer cell anchorage-independent growth and induction of apoptosis in BC cells.10, 12 In our published study, ISO was also reported to specifically suppress BC invasion through targeting the STAT1-FOXO1-MMP-2 axis.7 Here, SP1 is linked to cancer.