Real-Time PCR analysis showed that 2 lncRNAs and 1 circRNA were differentially expressed (DE) in serum exosomes of CRC patients compared to healthy individuals: in particular, UCA1 was downregulated, while circHIPK3 and TUG1 were upregulated (Table 1) (Figure 1A). The gene discussed is TUG1; the disease is colorectal carcinoma.