This hypothesis is in agreement with several papers reporting that CEBPB harbors a highly conserved MAPK consensus site, whose phosphorylation operated by MAPKs regulates its activity.48, 49, 50 Accordingly, CEBPB has been associated with several tumor models, including CRC, where it has shown increased expression compared to normal mucosa.51, 52. The gene discussed is CEBPB; the disease is colorectal carcinoma.