UCA1 and neoplasm: HOTAIR upregulation has also shown a positive correlation with poor prognosis, epithelial-mesenchymal transition (EMT), and metastasis in CRC patients.26, 27, 28 UCA1 expression is increased in tumor tissues of patients with lymph node metastasis compared to non-metastatic ones,29 and its upregulation correlates with tumor stage, poor prognosis, and metastasis.30