More specifically, 4 lncRNAs (CCAT1, CCAT2, HOTAIR, and UCA1) were upregulated, while 2 lncRNAs (MALAT1 and TUG1) and 1 circRNA (CDR1AS) were downregulated in CRC tumor tissues compared to NATs. The gene discussed is HOTAIR; the disease is colorectal carcinoma.