FXN and Friedreich ataxia: We analyzed the efficacy of previously selected plTALEVP64s to induce the expression of frataxin protein in the cells of two FRDA patients with a large number of repeats, FRDA4675 with 255/1,140 repeats (Figures 5D and 5E) and FRDA4743 having 470/970 repeats (Figures 5F and 5G).