We subsequently made new plTALEs fused with a 10× ST or 24× ST (plTALEST10Xs or plTALEST24Xs) (Figure 3A), which can recruit 10 or 24 scFv-sfGFP-VP64-GB1 (scFv) (Figure 3B) to further improve the transcription of the endogenous FXN gene in FRDA cells. The gene discussed is FXN; the disease is Friedreich ataxia.