Additionally, microRNAs (miRNAs) as important post-transcriptional regulators play crucial roles in multiple biological processes and diseases, and some related databases are built for further studies.10, 11 Some miRNAs were reported to serve as biomarkers to predict the prognosis of child T-ALL, such as miR-181 and miR-451.12, 13 Meanwhile, transcription factors (TFs) as regulators of gene expression may promote or inhibit the progression of T-ALL, such as KLF4 and TAL1/SCL. Here, KLF4 is linked to acute lymphoblastic leukemia.