Previous studies have focused on the genetic and epigenetic abnormalities in pediatric T-ALL and identified some driver events, such as NOTCH1 mutation, DNA methylation, and leukemia-initiating cell escape.5, 6 Some genes (e.g., CFLAR and BTG3) have been considered as prognosis markers for the relapse of pediatric T-ALL.7 Here, NOTCH1 is linked to acute lymphoblastic leukemia.