The CTBP2, as a co-repressor in the NOTCH-signaling pathway, was stably downregulated in the relapse group (Figure 2); SERPINB9, as a granzyme B inhibitor significantly downregulated in main subtypes of pediatric ALL,23 was stably downregulated in the relapse group and consistent with the previous study. The gene discussed is GZMB; the disease is acute lymphoblastic leukemia.