AKT1 and acute lymphoblastic leukemia: Moreover, multiple significant biological pathways have been reported playing vital roles in the recurrence of T-ALL, such as PI3K/AKT and JAK/STAT pathways, which are involved in the proliferation and survival of the leukemia cells.8, 9 However, rare research investigated the difference of transcriptome profiling between the relapse and remission specimens at the initial status (before treatment), which may provide new insights for the precise treatment of pediatric T-ALL.